Brain Images of Normal Subjects

8.30

Arrival and registration

9.00

Welcome and introduction (Joanna Wardlaw):

Background to the process, aims and objectives of meeting, meeting format and deliverables

9.10-10.30

Current and ‘emerging’ brain image banks and atlases: Chair: Paul Matthews

5 minute presentations: population/sample covered, structure and main uses of bank/atlas, main challenges and how these have been overcome, future opportunities or challenges for brain image banking

10.30-12.00

Philosophical and statistical problems: ‘What is normal, what is needed to define normal, across the lifespan” Chair: Klaus Ebmeier

10 minute summary, highlighting major unresolved questions in brain imaging across the lifespan - Alan Evans

Discussion Topics:

1. What minimum image and metadata, and how much, are needed to define normality? (Chair: John Ashburner)
2. What can be done with existing/being acquired data to determine normality across the lifespan; what are likely gaps? (Chair: Monique Breteler)
3. Is it realistic to combine, in one image bank, image data from all stages of life? (Chair: James Boardman + Dominic Job)

Discussion Topics:

1. Consent, including for secondary uses, mental capacity, ‘selling data’, links with healthcare/industry, between country differences (Chair: Burkhard Schaefer)
2. Privacy, including anonymisation of image and metadata, levels of access to image data, (Chair: Hester Ward)
3. ‘Research tourism’, dealing with incidental findings or that develop clinical implications in future, longitudinal studies (Chair: Alison Murray)

Discussion Topics:

1. Harmonising core minimum image data and subject meta-data, definitions and variables (Chair: Aziz Sheik)
2. Database infrastructure, key functionalities, attributes of existing methods, identifiable gaps in functionality? (Chair: Dan Marcus)
3. Submitting new data; quality assurance, data provenance, processing data/segmentation, avoiding duplication of subjects (Chair: Albert Burger)

Keynote lecture. Paul Thompson “Brain image banks: essential international research infrastructures for the 21st Century”

Discussion Topics:

1. Atlas creation tools and registration issues – dealing with brain variability (Chair: Bernard Mazoyer)
2. Outputs: data sharing/citation/storage, how to share individuals’ and study data securely, prevent multiple uses of same image from different sites (Chair: Steve Pavis + David Wyper)
3. User interface: What functions are required? How is it best delivered? How to prevent unwanted use (eg trying to recreate original data); Different uses for research, clinicians, industry (Chair: Nick Fox)